Potassium canrenoate (INN, JAN) or canrenoate potassium (USAN) (brand names Venactone, Soldactone), also known as aldadiene kalium,[1] the potassium salt of canrenoic acid, is an aldosterone antagonist of the spirolactone group.[2] Like spironolactone, it is a prodrug, and is metabolized to active canrenone in the body.[3][4]
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Other names | SC-14266 |
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Routes of administration | Intravenous |
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Pharmacokinetic data | |
Metabolism | Hepatic |
Excretion | Renal and fecal |
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ECHA InfoCard | 100.016.868 |
Chemical and physical data | |
Formula | C22H29KO4 |
Molar mass | 396.568 g·mol−1 |
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Potassium canrenoate is notable in that it is the only clinically used antimineralocorticoid which is available for parenteral administration (specifically intravenous)[4][5] as opposed to oral administration.[6]
In the UK, it is unlicensed and only used for short term diuresis in oedema or heart failure in neonates or children under specialist initiation and monitoring.