RFX2 Knowpia

RFX2
Identifiers
Aliases	RFX2, regulatory factor X2
External IDs	OMIM: 142765 MGI: 106583 HomoloGene: 30980 GeneCards: RFX2
Gene location (Human)
Chr.	Chromosome 19 (human)
End	6,199,572 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	57,138,013 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; bronchial epithelial cell; ; left uterine tube; ; sural nerve; ; blood; ; pituitary gland; ; superficial temporal artery; ; anterior pituitary; ; skin of abdomen; ; sperm;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; secondary oocyte; ; ascending aorta; ; blood; ; lip; ; aortic valve; ; blastocyst; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; cytoplasm;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; cell differentiation; spermatogenesis; acrosome assembly; spermatid development; regulation of transcription by RNA polymerase II; cell projection organization; cilium assembly; positive regulation of transcription by RNA polymerase II; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	5990
	19725
	ENSG00000087903
	ENSMUSG00000024206
	P48378
	P48379
	NM_000635; NM_134433
	NM_009056; NM_027787
	NP_000626; NP_602309
	NP_033082; NP_082063
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-binding protein RFX2 is a protein that in humans is encoded by the RFX2 gene.^[5]^[6]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.^[6]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000087903 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024206 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pugliatti L, Derre J, Berger R, Ucla C, Reith W, Mach B (Sep 1992). "The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19". Genomics. 13 (4): 1307–10. doi:10.1016/0888-7543(92)90052-T. PMID 1505960.
^ ^a ^b "Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression)".