Retinoid_X_receptor_beta Knowpia

RXRB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H9U, 1UHL, 5HJP, 5I4V
Identifiers
Aliases	RXRB, DAUDI6, H-2RIIBP, NR2B2, RCoR-1, Retinoid X receptor beta, RXRbeta, RXR-beta
External IDs	OMIM: 180246 MGI: 98215 HomoloGene: 7923 GeneCards: RXRB
Gene location (Human)
Chr.	Chromosome 6 (human)
End	33,200,665 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,257,373 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; gastric mucosa; ; left lobe of thyroid gland; ; right coronary artery; ; right uterine tube; ; pituitary gland; ; canal of the cervix; ; tibial nerve; ; spleen; ; anterior pituitary;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; renal corpuscle; ; ankle; ; crypt of lieberkuhn of small intestine; ; motor neuron; ; fossa; ; ankle joint; ; condyle; ; superior frontal gyrus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription coactivator activity; zinc ion binding; metal ion binding; steroid hormone receptor activity; nuclear receptor activity; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II; steroid hormone mediated signaling pathway; intracellular receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6257
	20182
ENSG00000235712; ENSG00000231321; ENSG00000227322; ENSG00000204231; ENSG00000206289;
	ENSG00000228333
	ENSMUSG00000039656
	P28702; Q5STP9
	P28704
	NM_001270401; NM_001291989; NM_021976
	NM_001205214; NM_001205215; NM_001205216; NM_011306
	NP_001257330; NP_001278918; NP_068811; NP_068811.1
	NP_001192143; NP_001192144; NP_001192145; NP_035436
	Wikidata
View/Edit Human	View/Edit Mouse

Retinoid X receptor beta (RXR-beta), also known as NR2B2 (nuclear receptor subfamily 2, group B, member 2) is a nuclear receptor that in humans is encoded by the RXRB gene.^[5]^[6]

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.^[6]

Interactive pathway map edit

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|alt=Vitamin D Synthesis Pathway (view / edit)]]

Vitamin D Synthesis Pathway (view / edit)

^ The interactive pathway map can be edited at WikiPathways: "VitaminDSynthesis_WP1531".

References edit

^ ^a ^b ^c ENSG00000231321, ENSG00000227322, ENSG00000204231, ENSG00000206289, ENSG00000228333 GRCh38: Ensembl release 89: ENSG00000235712, ENSG00000231321, ENSG00000227322, ENSG00000204231, ENSG00000206289, ENSG00000228333 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039656 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fitzgibbon J, Gillett GT, Woodward KJ, Boyle JM, Wolfe J, Povey S (Jul 1993). "Mapping of RXRB to human chromosome 6p21.3". Annals of Human Genetics. 57 (Pt 3): 203–9. doi:10.1111/j.1469-1809.1993.tb01596.x. PMID 8257090. S2CID 26964941.
^ ^a ^b "Entrez Gene: RXRB retinoid X receptor, beta".

Further reading edit

Szanto A, Narkar V, Shen Q, Uray IP, Davies PJ, Nagy L (Dec 2004). "Retinoid X receptors: X-ploring their (patho)physiological functions". Cell Death and Differentiation. 11 (Suppl 2): S126–43. doi:10.1038/sj.cdd.4401533. PMID 15608692.
Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T, Chen JY, Staub A, Garnier JM, Mader S (Jan 1992). "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently". Cell. 68 (2): 377–95. doi:10.1016/0092-8674(92)90478-U. PMID 1310259. S2CID 40617478.
Fleischhauer K, Park JH, DiSanto JP, Marks M, Ozato K, Yang SY (Apr 1992). "Isolation of a full-length cDNA clone encoding a N-terminally variant form of the human retinoid X receptor beta". Nucleic Acids Research. 20 (7): 1801. doi:10.1093/nar/20.7.1801. PMC 312273. PMID 1315958.
Berrodin TJ, Marks MS, Ozato K, Linney E, Lazar MA (Sep 1992). "Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein". Molecular Endocrinology. 6 (9): 1468–78. doi:10.1210/mend.6.9.1331778. PMID 1331778. S2CID 24291055.
Epplen C, Epplen JT (1992). "The human cDNA sequence homologous to the mouse MHC class I promoter-binding protein gene contains four additional codons in lymphocytes". Mammalian Genome. 3 (8): 472–5. doi:10.1007/BF00356161. PMID 1514958. S2CID 1278904.
Yu VC, Delsert C, Andersen B, Holloway JM, Devary OV, Näär AM, Kim SY, Boutin JM, Glass CK, Rosenfeld MG (Dec 1991). "RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements". Cell. 67 (6): 1251–66. doi:10.1016/0092-8674(91)90301-E. PMID 1662118. S2CID 10354699.
Oñate SA, Tsai SY, Tsai MJ, O'Malley BW (Nov 1995). "Sequence and characterization of a coactivator for the steroid hormone receptor superfamily". Science. 270 (5240): 1354–7. Bibcode:1995Sci...270.1354O. doi:10.1126/science.270.5240.1354. PMID 7481822. S2CID 28749162.
Kooistra T, Lansink M, Arts J, Sitter T, Toet K (Sep 1995). "Involvement of retinoic acid receptor alpha in the stimulation of tissue-type plasminogen-activator gene expression in human endothelial cells". European Journal of Biochemistry. 232 (2): 425–32. doi:10.1111/j.1432-1033.1995.425zz.x. PMID 7556191.
Perlmann T, Jansson L (Apr 1995). "A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1". Genes & Development. 9 (7): 769–82. doi:10.1101/gad.9.7.769. PMID 7705655.
Forman BM, Umesono K, Chen J, Evans RM (May 1995). "Unique response pathways are established by allosteric interactions among nuclear hormone receptors". Cell. 81 (4): 541–50. doi:10.1016/0092-8674(95)90075-6. PMID 7758108. S2CID 3203590.
Zanaria E, Muscatelli F, Bardoni B, Strom TM, Guioli S, Guo W, Lalli E, Moser C, Walker AP, McCabe ER (Dec 1994). "An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita". Nature. 372 (6507): 635–41. Bibcode:1994Natur.372..635Z. doi:10.1038/372635a0. PMID 7990953. S2CID 4363344.
Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM (Apr 1994). "Chromosomal localization of the human retinoid X receptors". Genomics. 20 (3): 397–403. doi:10.1006/geno.1994.1193. PMID 8034312.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Fleischhauer K, McBride OW, DiSanto JP, Ozato K, Yang SY (Jan 1993). "Cloning and chromosome mapping of human retinoid X receptor beta: selective amino acid sequence conservation of a nuclear hormone receptor in mammals". Human Genetics. 90 (5): 505–10. doi:10.1007/BF00217449. PMID 8381386. S2CID 26472949.
May M, Mengus G, Lavigne AC, Chambon P, Davidson I (Jun 1996). "Human TAF(II28) promotes transcriptional stimulation by activation function 2 of the retinoid X receptors". The EMBO Journal. 15 (12): 3093–104. doi:10.1002/j.1460-2075.1996.tb00672.x. PMC 450252. PMID 8670810.
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Joyeux A, Cavaillès V, Balaguer P, Nicolas JC (Feb 1997). "RIP 140 enhances nuclear receptor-dependent transcription in vivo in yeast". Molecular Endocrinology. 11 (2): 193–202. doi:10.1210/mend.11.2.9884. PMID 9013766.
Xu XC, Sozzi G, Lee JS, Lee JJ, Pastorino U, Pilotti S, Kurie JM, Hong WK, Lotan R (May 1997). "Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development". Journal of the National Cancer Institute. 89 (9): 624–9. doi:10.1093/jnci/89.9.624. PMID 9150186.
Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM (Aug 1997). "Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300". Cell. 90 (3): 569–80. doi:10.1016/S0092-8674(00)80516-4. PMID 9267036. S2CID 15284825.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[WikiPathways-7] The interactive pathway map can be edited at WikiPathways: "VitaminDSynthesis_WP1531".

[refGRCh38Ensembl-1] ENSG00000231321, ENSG00000227322, ENSG00000204231, ENSG00000206289, ENSG00000228333 GRCh38: Ensembl release 89: ENSG00000235712, ENSG00000231321, ENSG00000227322, ENSG00000204231, ENSG00000206289, ENSG00000228333 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039656 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8257090-5] Fitzgibbon J, Gillett GT, Woodward KJ, Boyle JM, Wolfe J, Povey S (Jul 1993). "Mapping of RXRB to human chromosome 6p21.3". Annals of Human Genetics. 57 (Pt 3): 203–9. doi:10.1111/j.1469-1809.1993.tb01596.x. PMID 8257090. S2CID 26964941.

[entrez-6] "Entrez Gene: RXRB retinoid X receptor, beta".

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Summary

Interactive pathway map edit

See also edit

References edit

Further reading edit