Angiopoietin-1 receptor also known as CD202B (cluster of differentiation 202B) is a protein that in humans is encoded by the TEK gene.[5][6] Also known as TIE2, it is an angiopoietin receptor.
TEK | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | TEK, CD202B, TIE-2, TIE2, VMCM, VMCM1, TEK tyrosine kinase, TEK receptor tyrosine kinase, GLC3E | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 600221 MGI: 98664 HomoloGene: 397 GeneCards: TEK | ||||||||||||||||||||||||||||||||||||||||||||||||||
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The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. (TEK is closely related to the TIE receptor tyrosine kinase.)[7]
This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats.[8] The ligand for the receptor is angiopoietin-1.[7] TEK has also been suggested as a marker for nucleus pulposus progenitor cells, from the intervertebral disc, which upon activation by Angiopoietin-1 starts to multiply and differentiate.[9][10]
Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis.[7]
In cancer patients, TEK (Tie2) is expressed in a subpopulation of monocytes that home in on the tumor and are essential for the formation of new blood vessels there.[11]
TEK tyrosine kinase has been shown to interact with:
This article incorporates text from the United States National Library of Medicine, which is in the public domain.