Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.[5][6][7]
TRIB3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | TRIB3, C20orf97, NIPK, SINK, SKIP3, TRB3, tribbles pseudokinase 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 607898 MGI: 1345675 HomoloGene: 10902 GeneCards: TRIB3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. It is a pseudoenzyme that is thought to be a negative regulator of NF-kappaB, and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein has been reported to negatively regulate the cell survival serine-threonine kinase AKT1.[7] TRIB3 has recently been associated with neuronal signalling, and like TRIB1 and TRIB2, could be considered as a potential allosteric drug target [8][9]
TRIB3 has been shown to interact with: