WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1), also known as Atg18 protein homolog (ATG18) and WD40 repeat protein interacting with phosphoinositides of 49 kDa (WIPI 49 kDa), is a protein that in humans is encoded by the WIPI1 gene.[5][6][7]
WIPI1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | WIPI1, ATG18, ATG18A, WIPI49, WD repeat domain, phosphoinositide interacting 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 609224 MGI: 1261864 HomoloGene: 117983 GeneCards: WIPI1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein–protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids.[5][7]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.