CYP3A7 is an enzyme belonging to the cytochrome P450 family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults.[5] The gene location is 7q22.1.[6]
CYP3A7 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CYP3A7, CP37, CYPIIIA7, P-450(HFL33), P-450111A7, P450-HFLA, cytochrome P450 family 3 subfamily A member 7, P450HLp2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 605340 MGI: 88610 HomoloGene: 133564 GeneCards: CYP3A7 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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The CYP3A group of enzymes are the most abundantly expressed members of the cytochrome P450 family in liver. They are responsible for the metabolism of more than 50% of all clinical pharmaceuticals.[7]
The CYP3A7 enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The CYP3A7 gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene.[8]
The CYP3A7*1C allele is associated with poor outcomes in some cancer patients, possibly because of the effect of the enzyme on some chemotherapy agents.[9]