Chromosome 7 is one of the 23 pairs of chromosomes in humans, who normally have two copies of this chromosome. Chromosome 7 spans about 160 million[4] base pairs (the building material of DNA) and represents between 5 and 5.5 percent of the total DNA in cells.
Chromosome 7 | |
---|---|
Features | |
Length (bp) | 160,567,428 bp (CHM13) |
No. of genes | 862 (CCDS)[1] |
Type | Autosome |
Centromere position | Submetacentric[2] (60.1 Mbp[3]) |
Complete gene lists | |
CCDS | Gene list |
HGNC | Gene list |
UniProt | Gene list |
NCBI | Gene list |
External map viewers | |
Ensembl | Chromosome 7 |
Entrez | Chromosome 7 |
NCBI | Chromosome 7 |
UCSC | Chromosome 7 |
Full DNA sequences | |
RefSeq | NC_000007 (FASTA) |
GenBank | CM000669 (FASTA) |
The following are some of the gene count estimates of human chromosome 7. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.[5]
Estimated by | Protein-coding genes | Non-coding RNA genes | Pseudogenes | Source | Release date |
---|---|---|---|---|---|
CCDS | 862 | — | — | [1] | 2016-09-08 |
HGNC | 870 | 245 | 703 | [6] | 2017-05-12 |
Ensembl | 984 | 973 | 889 | [7] | 2017-03-29 |
UniProt | 944 | — | — | [8] | 2018-02-28 |
NCBI | 948 | 905 | 933 | [9][10][11] | 2017-05-19 |
The following is a partial list of genes on human chromosome 7. For complete list, see the link in the infobox on the right.
The following diseases are some of those related to genes on chromosome 7:
The following conditions are caused by changes in the structure or number of copies of chromosome 7:
While a few of the specific genes related to Williams syndrome have been identified, the relationship between most of the genes in the deleted region and the signs and symptoms of Williams syndrome is unknown.
Chr. | Arm[29] | Band[30] | ISCN start[31] |
ISCN stop[31] |
Basepair start |
Basepair stop |
Stain[32] | Density |
---|---|---|---|---|---|---|---|---|
7 | p | 22.3 | 0 | 227 | 1 | 2,800,000 | gneg | |
7 | p | 22.2 | 227 | 397 | 2,800,001 | 4,500,000 | gpos | 25 |
7 | p | 22.1 | 397 | 610 | 4,500,001 | 7,200,000 | gneg | |
7 | p | 21.3 | 610 | 908 | 7,200,001 | 13,700,000 | gpos | 100 |
7 | p | 21.2 | 908 | 965 | 13,700,001 | 16,500,000 | gneg | |
7 | p | 21.1 | 965 | 1121 | 16,500,001 | 20,900,000 | gpos | 100 |
7 | p | 15.3 | 1121 | 1419 | 20,900,001 | 25,500,000 | gneg | |
7 | p | 15.2 | 1419 | 1589 | 25,500,001 | 27,900,000 | gpos | 50 |
7 | p | 15.1 | 1589 | 1816 | 27,900,001 | 28,800,000 | gneg | |
7 | p | 14.3 | 1816 | 1986 | 28,800,001 | 34,900,000 | gpos | 75 |
7 | p | 14.2 | 1986 | 2043 | 34,900,001 | 37,100,000 | gneg | |
7 | p | 14.1 | 2043 | 2327 | 37,100,001 | 43,300,000 | gpos | 75 |
7 | p | 13 | 2327 | 2639 | 43,300,001 | 45,400,000 | gneg | |
7 | p | 12.3 | 2639 | 2838 | 45,400,001 | 49,000,000 | gpos | 75 |
7 | p | 12.2 | 2838 | 2909 | 49,000,001 | 50,500,000 | gneg | |
7 | p | 12.1 | 2909 | 3093 | 50,500,001 | 53,900,000 | gpos | 75 |
7 | p | 11.2 | 3093 | 3306 | 53,900,001 | 58,100,000 | gneg | |
7 | p | 11.1 | 3306 | 3448 | 58,100,001 | 60,100,000 | acen | |
7 | q | 11.1 | 3448 | 3689 | 60,100,001 | 62,100,000 | acen | |
7 | q | 11.21 | 3689 | 3973 | 62,100,001 | 67,500,000 | gneg | |
7 | q | 11.22 | 3973 | 4171 | 67,500,001 | 72,700,000 | gpos | 50 |
7 | q | 11.23 | 4171 | 4597 | 72,700,001 | 77,900,000 | gneg | |
7 | q | 21.11 | 4597 | 4994 | 77,900,001 | 86,700,000 | gpos | 100 |
7 | q | 21.12 | 4994 | 5108 | 86,700,001 | 88,500,000 | gneg | |
7 | q | 21.13 | 5108 | 5292 | 88,500,001 | 91,500,000 | gpos | 75 |
7 | q | 21.2 | 5292 | 5406 | 91,500,001 | 93,300,000 | gneg | |
7 | q | 21.3 | 5406 | 5661 | 93,300,001 | 98,400,000 | gpos | 75 |
7 | q | 22.1 | 5661 | 6129 | 98,400,001 | 104,200,000 | gneg | |
7 | q | 22.2 | 6129 | 6300 | 104,200,001 | 104,900,000 | gpos | 50 |
7 | q | 22.3 | 6300 | 6470 | 104,900,001 | 107,800,000 | gneg | |
7 | q | 31.1 | 6470 | 6683 | 107,800,001 | 115,000,000 | gpos | 75 |
7 | q | 31.2 | 6683 | 6867 | 115,000,001 | 117,700,000 | gneg | |
7 | q | 31.31 | 6867 | 7094 | 117,700,001 | 121,400,000 | gpos | 75 |
7 | q | 31.32 | 7094 | 7208 | 121,400,001 | 124,100,000 | gneg | |
7 | q | 31.33 | 7208 | 7364 | 124,100,001 | 127,500,000 | gpos | 75 |
7 | q | 32.1 | 7364 | 7449 | 127,500,001 | 129,600,000 | gneg | |
7 | q | 32.2 | 7449 | 7576 | 129,600,001 | 130,800,000 | gpos | 25 |
7 | q | 32.3 | 7576 | 7803 | 130,800,001 | 132,900,000 | gneg | |
7 | q | 33 | 7803 | 8031 | 132,900,001 | 138,500,000 | gpos | 50 |
7 | q | 34 | 8031 | 8371 | 138,500,001 | 143,400,000 | gneg | |
7 | q | 35 | 8371 | 8612 | 143,400,001 | 148,200,000 | gpos | 75 |
7 | q | 36.1 | 8612 | 8910 | 148,200,001 | 152,800,000 | gneg | |
7 | q | 36.2 | 8910 | 9080 | 152,800,001 | 155,200,000 | gpos | 25 |
7 | q | 36.3 | 9080 | 9350 | 155,200,001 | 159,345,973 | gneg |
In the novel Performance Anomalies, researchers at Stanford University identify mutations in the long (q) arm of chromosome 7 as underlying the accelerated nervous system of the spy protagonist Cono,[33] who receives the moniker Cono 7Q