Fibroblast_growth_factor_receptor_4 Knowpia

FGFR4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4QQ5, 4QQC, 4QQJ, 4QQT, 4QRC, 4R6V, 4TYE, 4TYG, 4TYI, 4TYJ, 4UXQ, 4XCU
Identifiers
Aliases	FGFR4, CD334, JTK2, TKF, fibroblast growth factor receptor 4
External IDs	OMIM: 134935 MGI: 95525 HomoloGene: 20461 GeneCards: FGFR4
Gene location (Human)
Chr.	Chromosome 5 (human)
End	177,098,144 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	55,316,572 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; upper lobe of left lung; ; right lung; ; body of pancreas; ; lower lobe of lung; ; spleen; ; right adrenal gland; ; kidney; ; metanephric glomerulus; ; gallbladder;
	Top expressed in
	left lung lobe; ; yolk sac; ; left lobe of liver; ; internal carotid artery; ; utricle; ; kidney; ; urethra; ; stria vascularis; ; adrenal gland; ; right lung;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; heparin binding; kinase activity; protein binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; fibroblast growth factor binding; fibroblast growth factor-activated receptor activity; ATP binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; endosome; Golgi apparatus; membrane; cell-cell junction; plasma membrane; integral component of plasma membrane; transport vesicle; extracellular region; endoplasmic reticulum; cytoplasm; receptor complex;
Biological process	glucose homeostasis; phosphorylation; phosphate ion homeostasis; response to bile acid; regulation of extracellular matrix disassembly; MAPK cascade; regulation of bile acid biosynthetic process; fibroblast growth factor receptor signaling pathway; regulation of lipid metabolic process; protein phosphorylation; positive regulation of gene expression; positive regulation of cell population proliferation; positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of proteolysis; protein autophosphorylation; peptidyl-tyrosine phosphorylation; cell migration; phosphatidylinositol phosphate biosynthetic process; positive regulation of catalytic activity; phosphatidylinositol-3-phosphate biosynthetic process; positive regulation of protein kinase B signaling; cholesterol homeostasis; angiogenesis; negative regulation of signal transduction; cell differentiation; negative regulation of apoptotic process; transmembrane receptor protein tyrosine kinase signaling pathway; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	2264
	14186
	ENSG00000160867
	ENSMUSG00000005320
	P22455
	Q03142
	NM_001291980; NM_002011; NM_022963; NM_213647; NM_001354984
	NM_008011
	NP_001278909; NP_002002; NP_075252; NP_998812; NP_001341913
	NP_032037
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334 (cluster of differentiation 334).

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.^[5] In a meta-analisis study, the functional polymorphism Gly388Arg (rs351855) of FGFR4 was observed to be significantly associated with nodal involvement and overall survival in patients with different types of cancer.^[6]

Interactions edit

Fibroblast growth factor receptor 4 has been shown to interact with FGF1.^[7]^[8]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160867 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005320 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: FGFR4 fibroblast growth factor receptor 4".
^ Frullanti, E (2011). "Meta and pooled analyses of FGFR4 Gly388Arg polymorphism as a cancer prognostic factor". Eur J Cancer Prev. 20 (4): 340–347. doi:10.1097/CEJ.0b013e3283457274. PMID 21412156. S2CID 29668012.
^ Loo, B B; Darwish K K; Vainikka S S; Saarikettu J J; Vihko P P; Hermonen J J; Goldman A A; Alitalo K K; Jalkanen M M (May 2000). "Production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor 4". Int. J. Biochem. Cell Biol. 32 (5). ENGLAND: 489–97. doi:10.1016/S1357-2725(99)00145-4. ISSN 1357-2725. PMID 10736564.
^ Kan, M; Wu X; Wang F; McKeehan W L (May 1999). "Specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase". J. Biol. Chem. 274 (22). UNITED STATES: 15947–52. doi:10.1074/jbc.274.22.15947. ISSN 0021-9258. PMID 10336501.