The galanin receptor is a G protein-coupled receptor, or metabotropic receptor which binds galanin.[1]
galanin receptor 1 | |||||||
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Identifiers | |||||||
Symbol | GALR1 | ||||||
Alt. symbols | GALNR1, GALNR | ||||||
NCBI gene | 2587 | ||||||
HGNC | 4132 | ||||||
OMIM | 600377 | ||||||
RefSeq | NM_001480 | ||||||
UniProt | P47211 | ||||||
Other data | |||||||
Locus | Chr. 18 q23 | ||||||
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galanin receptor 2 | |||||||
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Identifiers | |||||||
Symbol | GALR2 | ||||||
NCBI gene | 8811 | ||||||
HGNC | 4133 | ||||||
OMIM | 603691 | ||||||
RefSeq | NM_003857 | ||||||
UniProt | O43603 | ||||||
Other data | |||||||
Locus | Chr. 17 q25.3 | ||||||
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galanin receptor 3 | |||||||
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Identifiers | |||||||
Symbol | GALR3 | ||||||
NCBI gene | 8484 | ||||||
HGNC | 4134 | ||||||
OMIM | 603692 | ||||||
RefSeq | NM_003614 | ||||||
UniProt | O60755 | ||||||
Other data | |||||||
Locus | Chr. 22 q12.2-13.1 | ||||||
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Galanin receptors can be found throughout the peripheral and central nervous systems and the endocrine system. So far three subtypes are known to exist: GAL-R1, GAL-R2, and GAL-R3.[2] The specific function of each subtype remains to be fully elucidated, although as of 2009 great progress is currently being made in this respect with the generation of receptor subtype-specific knockout mice,[3][4] and the first selective ligands for galanin receptor subtypes. Selective galanin agonists are anticonvulsant,[5][6][7] while antagonists produce antidepressant and anxiolytic effects in animals,[8][9][10][11][12] so either agonist or antagonist ligands for the galanin receptors may be potentially therapeutic compounds in humans.