Beta-sarcoglycan is a protein that in humans is encoded by the SGCB gene.[5][6]
SGCB | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | SGCB, A3b, LGMD2E, SGC, sarcoglycan beta, LGMDR4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 600900 MGI: 1346523 HomoloGene: 195 GeneCards: SGCB | ||||||||||||||||||||||||||||||||||||||||||||||||||
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The dystrophin-glycoprotein complex (DGC) is a multisubunit protein complex that spans the sarcolemma and provides structural linkage between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. There are 3 main subcomplexes of the DGC: the cytoplasmic proteins dystrophin (DMD; MIM 300377) and syntrophin (SNTA1; MIM 601017), the alpha- and beta-dystroglycans (see MIM 128239), and the sarcoglycans (see, e.g., SGCA; MIM 600119) (Crosbie et al., 2000).[supplied by OMIM].[6]
Mutations in the SGCB gene are known to cause Limb-girdle muscular dystrophy, autosomal recessive 4 (LGMDR4).[7] This condition causes pelvic and shoulder muscle wasting, usually from childhood.