The sarcoglycans are a family of transmembrane proteins[1] (α, β, γ, δ or ε) involved in the protein complex responsible for connecting the muscle fibre cytoskeleton to the extracellular matrix, preventing damage to the muscle fibre sarcolemma through shearing forces.
Sarcoglycan beta/gamma/delta | |||||||||
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Identifiers | |||||||||
Symbol | Sarcoglycan_1 | ||||||||
Pfam | PF04790 | ||||||||
InterPro | IPR006875 | ||||||||
Membranome | 117 | ||||||||
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Sarcoglycan alpha/epsilon | |||||||||
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Identifiers | |||||||||
Symbol | Sarcoglycan_2 | ||||||||
Pfam | PF05510 | ||||||||
InterPro | IPR008908 | ||||||||
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The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle. The sarcoglycan complex is a subcomplex within the DGC and is composed of six muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta-, epsilon-,and zeta-sarcoglycan).[2] The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains.[3][4]
The disorders caused by the mutations of the sarcoglycans are called sarcoglycanopathies. Mutations in the α, β, γ or δ genes (not ε) encoding these proteins can lead to the associated limb-girdle muscular dystrophy.