Protein chip or protein array is a high throughput technique to detect protein, investigate protein function and interact and monitor their expression level. Protein array is utilized as a popular technology in basic research and biotechnology enterprises.
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The principle of protein array involves utilization of proteins on a surface that includes glass, membranes, microtiterwells, mass spectrometer plates and beads. Probe molecules labelled with fluorescent dye are also added to the array. A fluorescent signal is emitted by the probe while it reacts with the immobilized proteins. The fluorescent signal can be read by a laser scanner.
There are three types of protein chips available namely, large-scale functional chips, analytical capture arrays and lysate (reverse protein array). The major application areas of protein array includes diagnostics, proteomics, protein functional analysis and antibody characterization. The advantage of protein array includes rapid and automated technology, economical, gather abundant data by a single experiment. Thus, all the above mentioned factors collectively supports the growth of protein array in the global market.
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The global protein chip market can be categorized based on the following:
By technology
- Analytical microarrays
- Functional protein microarrays
- Reverse phase protein microarray
By application
- Diagnostics
- Proteomics
- Protein functional analysis
- Antibody characterization
Technological advancements in diagnostic tests and increasing prevalence of cancer are the major factors driving the protein chip market globally. Moreover, rising awareness for personalized medicine also accentuates the global protein chip market. However, lack of healthcare coverage and technical complexities associated with protein chip technology may hinder the global market growth majorly in developing countries.
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Geographically, North America and Europe dominates the global market for protein chipdue to strong demand for molecular-based diagnostics techniques and increased awareness among patient population. Asia–Pacific is considered as an emerging market in protein chip technology owing to the financial improvement of some the Asian countries such as India, China and Malaysia.
Moreover, most of the drug development companies outsourced their clinical trial drug development studies in Asian countries owing to its large pool of population. Thus, the above mentioned factors accentuates the growth of protein chip market in this region.
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Some of the market players operating in this industry segment include EMD Millipore, Illumina, Inc., Life Technologies Corporation, SEQUENOM, Inc., Sigma Aldrich Corporation, Affymetrix, Inc. and Agilent Technologies.
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