The next generation immune checkpoint inhibitors and stimulators market is projected to grow at an annualized rate of ~15%, till 2030

Roots Analysis has done a detailed study on Next Generation Immune Checkpoint Inhibitors and Stimulators Market, 2020-2030, covering key aspects of the industry’s evolution and identifying potential future growth opportunities.

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Key Market Insights

§  More than 150 industry players across the world are presently engaged in evaluating the potential of nearly 300 next generation immune checkpoint modulators for the treatment of multiple disease indications

§  The pipeline features a variety of marketed / clinical stage therapies, targeting a number of different types of immune checkpoints and being investigated for administration via different routes

§  In the last few years, over 600 clinical studies of various types of immune checkpoint modulation-based therapies, involving nearly 90,000 patients across different centers / hospitals, have been initiated worldwide

§  In the pursuit of obtaining an edge within this emerging and highly competitive market landscape, developers are actively exploring the therapeutic potential of novel immune checkpoints, beyond PD-L1, PD-1 and CTLA-4

§  Over time, big pharma players have initiated product development programs focused on immune checkpoint modulation for treating various oncological indications, investing significant capital, time and effort

§  Several organizations have extended financial support to aid research efforts in this domain; the current focus is on investigation of novel immune checkpoint pathways / targets

§  The growing interest in this field is also reflected by the 120+ partnerships have been signed in the last two years, involving both international and indigenous stakeholders

§  The future market, based on the revenue generation potential of marketed and late stage therapies, is anticipated to be distributed across different disease areas, mechanisms and key geographical regions

§  In the long term, the opportunity is likely to be segmented across diverse therapeutic modalities, immune checkpoint targets and routes of administration

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Table of Contents

1.         PREFACE
1.1.       Scope of the Report
1.2.       Research Methodology
1.3.       Chapter Outlines

2.         EXECUTIVE SUMMARY

3.         INTRODUCTION
3.1.       Chapter Overview
3.2.       Introduction to Cancer Immunotherapy
3.3.       Fundamentals of Cancer Immunotherapy
3.4.       Immune Checkpoint Modulators
3.5.       First Generation Immune Checkpoint Modulators
3.6.       Next Generation Immune Checkpoint Modulators
3.6.1.    Types of Next Generation Immune Checkpoint Modulators

3.7.       Challenges-related to Immune Checkpoint Modulation-based Therapy
3.8.       Future Perspectives

4.         CURRENT MARKET LANDSCAPE: CLINICAL AND PRECLINICAL MOLECULES
4.1.       Chapter Overview
4.2.       Next Generation Immune Checkpoint Inhibitors and Stimulators: Marketed and Development        Pipeline

4.3.       Next Generation Immune Checkpoint Inhibitors and Stimulators: Pipeline Analysis
4.3.1.    Analysis by Phase of Development
4.3.2.    Analysis by Target Immune Checkpoint
4.3.3.    Analysis by Mechanism of Action
4.3.4.    Analysis by Therapeutic Modality
4.3.5.    Analysis by Route of Administration
4.3.6.    Analysis by Target Disease Indication
4.3.7.    Analysis by Therapeutic Area
4.3.8.    Analysis by Type of Therapy
4.3.9.    Funnel Representation: Analysis by Phase of Development, Mechanism of Action and Type of      Therapy

4.4.       Next Generation Immune Checkpoint Inhibitors and Stimulators: List of Drug Developers
4.4.1.    Analysis by Year of Establishment
4.4.2.    Analysis by Company Size and Geographical Location
4.4.3.    Leading Developer Companies: Analysis by Number of Pipeline Therapies
4.4.4.    World Map Representation: Analysis by Geography

5.         MARKET LANDSCAPE: THERAPIES TARGETING CD47
5.1.       Chapter Overview
5.2.       Next Generation Immune Checkpoint Inhibitors: Development Pipeline of CD47 Targeting             Therapies

5.3.       Next Generation Immune Checkpoint Inhibitors: Pipeline Analysis of CD47 Targeting Therapies
5.3.1.    Analysis by Phase of Development
5.3.2.    Analysis by Therapeutic Modality
5.3.3.    Analysis by Route of Administration
5.3.4.    Analysis by Target Disease Indication
5.3.5.    Analysis by Type of Therapy

5.4.       Next Generation Immune Checkpoint Inhibitors: List of Companies Developing CD47 Targeting    Therapies
5.4.1.    Analysis by Year of Establishment
5.4.2.    Analysis by Company Size and Geographical Location
5.4.3.    Leading Developers: Analysis by Number of Therapies
5.4.4.    World Map Representation: Analysis by Geography

6.         MARKET LANDSCAPE: THERAPIES TARGETING 4-1BB
6.1.       Chapter Overview
6.2.       Next Generation Immune Checkpoint Stimulators: Development Pipeline of 4-1BB Targeting         Therapies

6.3.       Next Generation Immune Checkpoint Stimulators: Pipeline Analysis of 4-1BB Targeting    Therapies
6.3.1.    Analysis by Phase of Development
6.3.2.    Analysis by Therapeutic Modality
6.3.3.    Analysis by Route of Administration
6.3.4.    Analysis by Target Disease Indication
6.3.5.    Analysis by Type of Therapy

6.4.       Next Generation Immune Checkpoint Stimulators: List of Companies Developing 4-1BB Targeting             Therapies
6.4.1.    Analysis by Year of Establishment
6.4.2.    Analysis by Company Size and Geographical Location
6.4.3.    Leading Developers: Analysis by Number of Therapies
6.4.4.    World Map Representation: Analysis by Geography

7.         CLINICAL TRIAL ANALYSIS 
7.1.       Chapter Overview
7.2.       Scope and Methodology
7.3.       Next Generation Immune Checkpoint Inhibitors and Stimulators: Clinical Trial Analysis
7.3.1.    Analysis by Trial Registration Year
7.3.2.    Analysis by Trial Phase
7.3.3.    Analysis by Trial Recruitment Status
7.3.4.    Analysis by Trial Registration Year and Number of Patients Enrolled
7.3.5.    Analysis by Study Design
7.3.6.    Analysis by Sponsor / Collaborator
7.3.7.    Leading Industry Sponsors: Analysis by Number of Registered Trials
7.3.8.    Word Cloud: Key Focus Areas
7.3.9.    Analysis by Target Immune Checkpoint 
7.3.10. Analysis by Target Therapeutic Area 
7.3.11. Popular Interventions: Analysis by Number of Registered Trials 
7.3.12. Geographical Analysis by Number of Registered Trials 
7.3.13. Geographical Analysis by Trial Recruitment Status 
7.3.14. Geographical Analysis by Number of Patients Enrolled 

8.         COMPANY PROFILES: NEXT GENERATION INHIBITORS AND STIMULATORS
8.1.       Chapter Overview
8.2.       Bristol-Myers Squibb
8.2.1.    Company Overview
8.2.2.    Financial Information
8.2.3.    Next Generation Immune Checkpoint Therapeutics Portfolio
8.2.4.    Recent Developments and Future Outlook

8.3.       Eli Lilly
8.3.1.    Company Overview
8.3.2.    Financial Information
8.3.3.    Next Generation Immune Checkpoint Therapeutics Portfolio
8.3.4.    Recent Developments and Future Outlook

8.4.       GlaxoSmithKline
8.4.1.    Company Overview
8.4.2.    Financial Information
8.4.3.    Next Generation Immune Checkpoint Therapeutics Portfolio
8.4.4.    Recent Developments and Future Outlook

8.4.       Novartis
8.4.1.    Company Overview
8.4.2.    Financial Information
8.4.3.    Next Generation Immune Checkpoint Therapeutics Portfolio
8.4.4.    Recent Developments and Future Outlook

8.5.       XOMA
8.5.1.    Company Overview
8.5.2.    Financial Information
8.5.3.    Next Generation Immune Checkpoint Therapeutics Portfolio
8.5.4.    Recent Developments and Future Outlook

9.         ACADEMIC GRANTS ANALYSIS
9.1.       Chapter Overview
9.2.       Scope and Methodology

9.3.       Next Generation Immune Checkpoint Inhibitors and Stimulators: Analysis of Grants Awarded by   the National Institutes of Health (NIH)
9.3.1.    Analysis by Year of Grant Award
9.3.2.    Analysis by Amount Awarded
9.3.3.    Analysis by Administering Institute Center
9.3.4.    Analysis by Funding Institute Center
9.3.5.    Analysis by Support Period
9.3.6.    Analysis by Funding Institute Center and Support Period
9.3.7.    Analysis by Type of Grant Application
9.3.8.    Analysis by Purpose of Grant Award
9.3.9.    Analysis by Grant Mechanism
9.3.10. Word Cloud: Emerging Focus Areas
9.3.11. Popular Target Immune Checkpoints: Analysis by Number of Grants
9.3.12. Analysis of Grant Amount Awarded by Target Immune Checkpoints
9.3.13. Analysis by Study Section Involved
9.3.14. Analysis by Types of Recipient Organizations
9.3.15. Popular Recipient Organizations: Analysis by Number of Grants
9.3.16. Prominent Program Officers: Analysis by Number of Grants
9.3.17. Regional Analysis of Recipient Organizations
9.4.       Grant Attractiveness Analysis

10.        PARTNERSHIPS AND COLLABORATIONS
10.1.     Chapter Overview
10.2.     Partnership Models

10.3.     Next Generation Immune Checkpoint Inhibitors and Stimulators: List of Partnerships and Collaborations
10.3.1. Analysis by Year of Partnership
10.3.2. Analysis by Type of Partnership
10.3.3. Analysis by Target Immune Checkpoint
10.3.4. Analysis by Year of Partnership and Target Immune Checkpoint
10.3.5. Analysis by Type of Partnership and Target Immune Checkpoint
10.3.6. Analysis by Type of Partnership and Target Disease Indication
10.3.7. Analysis by Year and Type of Partner
10.3.8. Most Active Players: Analysis by Number of Partnerships
10.3.9. Regional Analysis
10.3.10. Intercontinental and Intracontinental Agreements

11.        TARGET COMPETITIVENESS ANALYSIS
11.1.     Chapter Overview
11.2.     Scope and Methodology
11.3.     Competitiveness Analysis: Key Targets for Next Generation Immune Checkpoint Inhibitors and     Stimulators
11.3.1. Four-Dimensional Bubble Analysis
11.3.2. Five-Dimensional Spider Web Analysis

12.        BIG PHARMA INITIATIVES
12.1.     Chapter Overview
12.2.     Big Pharma Initiatives Focused on Next Generation Immune Checkpoint
12.2.1. Analysis by Number of Initiatives
12.2.2. Analysis by Product Development Strategy
12.2.4. Analysis by Target Immune Checkpoint Modulators
12.2.5. Grid Representation: Analysis by Product Development Strategy and Target Immune Checkpoint
12.2.6. Analysis by Therapeutic Area

13.        MARKET FORECAST AND OPPORTUNITY ANALYSIS
13.1.     Chapter Overview
13.2.     Forecast Methodology and Key Assumptions
13.3.     Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market, 2020-2030

13.4.     Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market: Individual Product             Sales Forecasts

13.4.1. DARZALEX® (Janssen Pharmaceuticals)
13.4.2. GSK3359609 (GlaxoSmithKline)
13.4.3.  RRx-001 (EpicentRx)
13.4.4. SAR650984 (Sanofi)
13.4.5. MGA271 (MacroGenics)
13.4.6. Omburtamab (Y-mAbs Therapeutics)
13.4.7. AMG557 (Amgen)
13.4.8. APX005M (Apogenix)
13.4.9. BI 655064 (Boehringer Ingelheim)
13.4.10. Dapirolizumab Pegol (UCB Pharma)

13.5.     Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market: Distribution by      Region
13.5.1. Next Generation Immune Checkpoint Inhibitors and Stimulators Market in North America, 2020-    2030
13.5.2. Next Generation Immune Checkpoint Inhibitors and Stimulators Market in Europe, 2020-2030
13.5.3. Next Generation Immune Checkpoint Inhibitors and Stimulators Market in Asia-Pacific, 2020-        2030
13.5.4. Next Generation Immune Checkpoint Inhibitors and Stimulators Market in Rest of the World,         2020-2030

13.6.     Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market: Distribution by      Target Disease Indication
13.6.1. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for Colorectal        Cancer, 2020-2030
13.6.2. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for Head and Neck             Cancer, 2020-2030
13.6.3. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for Hematological Malignancies, 2020-2030
13.6.4. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for Lung Cancer,   2020-2030
13.6.5. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for Melanoma,       2020-2030
13.6.6. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for            Neuroblastoma, 2020-2030
13.6.7. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for Non-    Oncological Indications, 2020-2030

13.7.     Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market: Distribution by      Target Immune Checkpoint
13.7.1. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for B7-H3 Targeting Therapies, 2020-2030
13.7.2. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for CD38   Targeting Therapies, 2020-2030
13.7.3. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for CD40   Targeting Therapies, 2020-2030
13.7.4. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for CD47   Targeting Therapies, 2020-2030
13.7.5. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for ICOS Targeting             Therapies, 2020-2030

13.8.     Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market: Distribution by      Mechanism of Action
13.8.1. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for Inhibitory          Therapies, 2020-2030
13.8.2. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for Stimulatory       Therapies, 2020-2030

13.9.     Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market: Distribution by Type of Therapeutic Modality
13.9.1. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for Antibody          Fragments, 2020-2030
13.9.2. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for Monoclonal      Antibodies, 2020-2030
13.9.3. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for Small Molecule             Drugs, 2020-2030

13.10.   Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market: Distribution by      Type of Therapy
13.10.1. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for Monotherapy, 2020-2030
13.10.2. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for Combination    Therapy, 2020-2030
13.10.3. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for Both, 2020-     2030

13.11. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market: Distribution by        Route of Administration
13.11.1. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for             Intracerebroventricular Therapies, 2020-2030
13.11.2. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for Intravenous     Therapies, 2020-2030
13.11.3. Global Next Generation Immune Checkpoint Inhibitors and Stimulators Market for Subcutaneous             Therapies, 2020-2030

14.        CONCLUDING REMARKS

15.        EXECUTIVE INSIGHTS

16.        APPENDIX 1: TABULATED DATA

17.        APPENDIX 2: LIST OF COMPANIES AND ORGANIZATIONS

Contact Details

Gaurav Chaudhary

+1 (415) 800 3415

gaurav.chaudhary@rootsanalysis.com