Global Liposome Drug Delivery
Market: Introduction
According to the report, the
global liposome drug delivery market was
valued at US$ 3.6 Bn in 2018 and is projected to expand at a considerable CAGR
during the forecast period. Liposomes are considered novel drug delivery
systems and defined as the vesicular structures consisting of bilayers formed
spontaneously when phospholipids are dispersed in water. Liposomes aid in
delivering drugs by the process of diffusion rather than direct cell fusion.
The global liposome drug delivery market is driven by increase in therapeutic
and diagnostic applications. Therapeutic applications include anti-fungal,
anti-cancer, and anti-inflammatory drugs, in addition to therapeutic gene
delivery. Major drugs formulated using liposome drug delivery are Doxil,
AmBisome, and DepoDur. Liposomes also play an integral part in individualized
medicine. Applications include accurate disease diagnosis, monitoring drug
delivery, determining therapy response, and guiding minimally invasive
surgeries.
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North America dominated the
global liposome drug delivery market in 2018 and the trend is anticipated to
continue during the forecast period. The U.S. FDA received over 400 liposomal
drug product submissions in the past few years; over eight products have been
approved for sale in the U.S. Among the product submissions received, over 96%
were investigational new drug (IND) applications, around 3% were new drug
applications (NDAs), and over 1% were abbreviated new drug applications
(ANDAs).
Advantages of Liposome Drug
Delivery
Liposomes are considered highly
common and well-investigated nanocarriers for targeted drug delivery. Liposomes
can be defined as phospholipid vesicles, which consist of one or more
concentric lipid bilayers enclosed in discrete aqueous spaces. Both
conventional and stealth liposomes have a natural ability to enhance the
localization of anticancer drugs to solid tumors through the process of passive
targeting. Liposomes are also effective in carrying both positively and
negatively charged molecules, which offer a degree of protection to the DNA
from the degradative process, and can carry large pieces of DNA, preferably as
large as a chromosome. These advantages make liposomes effective drug delivery
systems, which contributes to the growth of the global liposome drug delivery
market.
Liposomal Doxorubicin to Lead
Global Market
In terms of product, the PyroGene
brand is likely to account for a major share of the global liposome drug
delivery market during the forecast period. The products developed using
liposomal doxorubicin include Doxil, which aids in the treatment of
HIV-associated Kaposi sarcoma. Moreover, products developed by employing this
product help reduce the toxicity and side effects associated with the
administration of doxorubicin.
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Extensive Utilization of
Stealth Liposome Technology in Liposome Drug Formulations
In terms of technology, the
stealth liposome technology segment is likely to account for a major share of
the global liposome drug delivery market during the forecast period. Stealth
liposome technology is extensively utilized in liposome drug formulations. The
first of the liposomal drugs employed for human use were developed using this
technology. Growth of the segment can be attributed to the presence of marketed
drugs developed using this technology.
Liposome Drug Delivery Market:
Prominent Regions
The global liposome drug delivery
market has been segmented into five major regions: North America, Europe, Asia
Pacific, Latin America, and Middle East & Africa. North America dominated
the global liposome drug delivery market in 2018. The U.S. is the major market
in the region. Growth of the market in the region can be attributed to significant
investments in research & development, rich pipeline of drugs, strong
presence of leading players, rise in prevalence of cancer & other chronic
diseases, and well-established healthcare infrastructure.
The liposome drug delivery market
in Asia Pacific is projected to expand at a high CAGR from 2019 to 2027. The
market in the region is anticipated to be driven by developing countries such
as China and India. Rise in focus of market players on strengthening presence
in emerging economies in order to leverage growth opportunities propels the
market in Asia Pacific. Fujifilm Toyama Chemical constructed a new
manufacturing facility at its Toyama Second Factory in Japan for the
manufacture of liposomal formulations.
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Significant Pipeline of Drugs
by Key Players to Propel Global Market
The global liposome drug delivery
market is fragmented in terms of number of players. Key players operating in
the global liposome drug delivery market are Spectrum Pharmaceuticals, Inc.,
Astellas Pharma, Inc., Gilead Sciences, Inc., Celsion Corporation, Ipsen Pharma,
Pacira BioSciences, Inc., Luye Pharma Group, Novartis AG, Takeda Pharmaceutical
Company Limited, and Johnson & Johnson, among others.
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