Roots Analysis has announced the
addition of “Targeted Protein Degradation Market, 2021-2030” report
to its list of offerings.
Small-molecule-induced protein degradation has
been demonstrated to possess the potential to drug a broader range of proteinaceous
biological targets. It involves the selective recruitment of the body’s
inherent protein degradation pathways, to eliminate disease causing /
associated proteins, using bifunctional small molecule drugs. Presently, the
most popular and promising class of interventions in this field of research, is
proteolysis targeting chimeras (PROTACs); these can simultaneously bind a
target protein and an E3-ubiquitin ligase, and thereby, facilitate the
selective ubiquitination and eventual proteasome-mediated degradation of the
target protein. The most interesting feature of this mechanism of drug action
is the fact that PROTACs and other targeted protein degraders can eliminate protein
targets regardless of their function.
To order this 330+ page report, which
features 115+ figures and 180+ tables, please visit –
https://www.rootsanalysis.com/reports/289/request-sample.html
Key Market
Insights
Presently,
more than 150 targeted protein degradation-based therapeutics are currently
under development
Around 75% of the
aforementioned candidates are in the preclinical and discovery stages, followed
by those that are being evaluated in clinical trials (25%). The these degrader
molecules are PROTAC (26), followed by DUB inhibitors (15%), protein
homeostatic modulators (14%) and SERDs/SARDs (13%).
Over
40 targeted protein degradation enabling technologies are presently available /
under development
Of these, the PROTAC®
platform is presently considered the most popular, with 15 product candidates,
developed using the same technology, under investigation. On the other hand,
there are presently 10 technologies that are designed to design / develop DUB
inhibitors.
Around 80
companies claim to be engaged in the development of targeted protein
degradation-based therapeutics
Post 2010,
there has been a notable surge in the number of companies developing targeted
protein degraders. Majority of the firms engaged in this field (57%) are based
in North America, followed by Europe (27%) and the Asia Pacific (16%).
Over
80 registered clinical trials are presently assessing targeted protein
degradation-based therapeutics, worldwide
It is
worth mentioning that most of the clinical research in this direction is being
conducted in Europe (60%), followed by North America and the Asia Pacific. However,
more than 40% of the total number of patients enrolled in such trials are in North
America.
Over 770 grants have been awarded to support research on targeted
protein degradation-based therapeutics, since 2016
An
estimate total of USD 345 million in grants have been awarded to various
organizations working in this domain, during the period between January 2016 to
December 2020. Almost 40% of the total number of grants were provided by the
National Cancer Institute.
The USD 3.3
billion (by 2030) financial opportunity within the targeted protein degradation
enabling technologies market has been analyzed across the following segments:
§
§
§
§
§
§
§
§
§
§
- Oncological
Disorders
- Neurological
Disorders
- Others
§
§
§
§
§
§
§
§
The
research includes detailed profiles of key players (listed below); each
profile features an overview of the company, its financial information (if available), brief descriptions
of its proprietary drug(s) and an informed future outlook.
§
§
§
§
§
§
§
§
§
§
§
§
§
§
§
For additional details, please
visit
https://www.rootsanalysis.com/reports/view_document/protein-degradation-market/289.html
or email sales@rootsanalysis.com
You may also be interested in the
following titles:
2.
3.
About Roots Analysis
Roots Analysis is one of the fastest growing
market research companies, sharing fresh and independent perspectives in the
bio-pharmaceutical industry. The in-depth research, analysis and insights are
driven by an experienced leadership team which has gained many years of
significant experience in this sector. If you’d like help with your growing
business needs, get in touch at info@rootsanalysis.com
Contact Information
Roots
Analysis Private Limited
Gaurav Chaudhary
+1 (415) 800 3415
Facebook - https://www.facebook.com/RootsAnalysis
LinkedIn - https://www.linkedin.com/company/roots-analysis/mycompany/
Twitter - https://twitter.com/RootsAnalysis
