Roots Analysis has done a detailed study on ““In Vitro ADME Testing Services Market,
2019-2030” covering key aspects
of the industry’s evolution and identifying potential future growth
opportunities.
To order this 280+ page report, which features
135+ figures and 120+ tables, please visit this link
Key Market Insights
§ Over 90 firms are
actively involved in providing vitro ADME testing services; of
these, over 30 players claim to have the capabilities to offer end-to-end
services
§ Majority of the
companies offer assays for drug metabolism and elimination testing for both
small molecule and biologic drugs; followed by companies offering assays for
absorption and distribution testing
§ Featuring the
presence of small-mid sized firms, the in vitro ADME testing service
provider landscape is well-distributed across various regions; these players
have adopted various business models to cater to the evolving needs of the
clients
§ Several players involved in this domain are steadily expanding their
capabilities in order to enhance their respective in the in vitro ADME
testing service portfolios and maintain a competitive edge in this industry
§ Various mergers and
acquisitions have taken place from 2005-2018 between industry stakeholders in
this domain, for addition of
capabilities (primarily related to drug metabolism and pharmacokinetics testing)
and geographical expansion / consolidation
§ Driven by the
increasing demand for effective pharmacological interventions across a wide
range of therapeutic areas, the market is expected to witness sustained growth
in future
§ In the long-term, the projected opportunity is anticipated to be well
distributed across various geographies, type of sponsors and type of services /
assays
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Table
of Contents
1. PREFACE
1.1.
Scope of the Report
1.2.
Research Methodology
1.3.
Chapter Outlines
2. EXECUTIVE SUMMARY
3. INTRODUCTION
3.1. Chapter Overview
3.2. The Drug Discovery and Development Process
3.3. Introduction to Absorption, Distribution,
Metabolism and Excretion (ADME) Testing
3.3.1. Absorption
3.3.2. Distribution
3.3.3. Metabolism
3.3.4. Excretion
3.4. Importance of ADME Studies in Early Stage
Research
3.5. Types of ADME Studies in Discovery and
Preclinical Development
3.6. Types of Assays Used in ADME Testing
3.7. Types of ADME Testing Studies
3.7.1. In Vitro ADME Testing Studies
3.7.2. In Silico ADME Testing Studies
3.7.3. In Vivo ADME Testing Studies
3.8. Key Drivers for ADME Testing Studies
3.9. Concluding Remarks
4. GUDE TO OUTSOURCING
4.1. Chapter Overview
4.2. Outsourcing ADME Testing Services
4.3. Guiding Models for Outsourcing
4.3.1. Transactional Outsourcing Model
4.3.2. Performance-based Outsourcing Model
4.3.3. Outcomes-based Outsourcing Model
4.3.4. Phase-dependent Outsourcing Model
4.4. Selecting a Contract Research Organization
(CRO) Partner
4.4.1. Key Considerations
4.5. Role of CROs in Drug Development
4.5.1. Discovery and Preclinical Research
4.5.2. Early Clinical Research
4.5.3. Late Stage Clinical Research
4.6. Benefits of Outsourcing ADME Testing
Services
4.7. Risks and Challenges Associated with
Outsourcing ADME Testing Services
4.8. Concluding Remarks
5. MARKET LANDSCAPE
5.1. Chapter Overview
5.1. Chapter Overview
5.2. In Vitro ADME Testing Services: List of
Industry Players
5.2.1. Analysis by Year of Establishment
5.2.2. Analysis by Geographical Location
5.2.3. Analysis by Company Size
5.2.4. Analysis by Type of Service Offering
5.2.5. Analysis by Type of In Vitro ADME Assays
5.2.6. Analysis by Type of Molecule
5.2.7. Analysis by Type of Clientele
5.2.8. Logo Landscape: Distribution by Company Size
and Location of Headquarters
5.3. In Silico ADME Testing Services: List of
Industry Players
6. COMPANY PROFILES
6.1. Chapter Overview
6.2. Key Players based in North America
6.2.1. Albany Molecular Research (AMRI)
6.2.1.1. Company Snapshot
6.2.1.2. Financial Information
6.2.1.3. ADME Testing Specific Service Portfolio
6.2.1.4. Recent Developments and Future Outlook
6.2.2. Charles River Laboratories
6.2.2.1. Company Snapshot
6.2.2.2. Financial Information
6.2.2.3. ADME Testing Specific Service Portfolio
6.2.2.4. Recent Developments and Future Outlook
6.2.3. Pharmaceutical Product Development (PPD)
6.2.3.1. Company Snapshot
6.2.3.2. ADME Testing Specific Service Portfolio
6.2.3.3. Recent Developments and Future Outlook
6.2.4. RTI International
6.2.4.1. Company Snapshot
6.2.4.2. Financial Information
6.2.4.3. ADME Testing Specific Service Portfolio
6.2.4.4. Recent Developments and Future Outlook
6.3. Key Players based in Europe
6.3.1. Eurofins Scientific
6.3.1.1. Company Snapshot
6.3.1.2. Financial Information
6.3.1.3. ADME Testing Specific Service Portfolio
6.3.1.4. Recent Developments and Future Outlook
6.3.2. Evotec
6.3.2.1. Company Snapshot
6.3.2.2. Financial Information
6.3.2.3. ADME Testing Specific Service Portfolio
6.3.2.4. Recent Developments and Future Outlook
6.3.3. Galapagos
6.3.3.1. Company Snapshot
6.3.3.2. Financial Information
6.3.3.3. ADME Testing Specific Service Portfolio
6.3.3.4. Recent Developments and Future Outlook
6.3.4. Tecan Group
6.3.4.1. Company Snapshot
6.3.4.2. Financial Information
6.3.4.3. ADME Testing Specific Service Portfolio
6.3.4.4. Recent Developments and Future Outlook
6.4. Key Players based in Asia-Pacific
6.4.1. GVK Biosciences
6.4.1.1. Company Snapshot
6.4.1.2. ADME Testing Specific Service Portfolio
6.4.1.3. Recent Developments and Future Outlook
6.4.2. Pharmaron
6.4.2.1. Company Snapshot
6.4.2.2. ADME Testing Specific Service Portfolio
6.4.2.3. Recent Developments and Future Outlook
6.4.3. Sai Life Sciences
6.4.3.1. Company Snapshot
6.4.3.2. ADME Testing Specific Service Portfolio
6.4.3.3. Recent Developments and Future Outlook
6.4.4. Shanghai Medicilon
6.4.4.1. Company Snapshot
6.4.4.2. ADME Testing Specific Service Portfolio
6.4.4.3. Recent Developments and Future Outlook
6.4.5. Syngene International
6.4.5.1. Company Snapshot
6.4.5.2. Financial Information
6.4.5.3. ADME Testing Specific Service Portfolio
6.4.5.4. Recent Developments and Future Outlook
6.4.6. WuXi AppTec
6.4.6.1. Company Snapshot
6.4.6.2. Financial Information
6.4.6.3. ADME Testing Specific Service Portfolio
6.4.6.4. Recent Developments and Future Outlook
7. BENCHMARK ANALYSIS
7.1. Chapter Overview
7.2. Benchmark Analysis: Methodology
7.3. Benchmark Analysis: Peer Groups
7.3.1. Peer Group I
7.3.2. Peer Group II
7.3.3. Peer Group III
7.3.4. Peer Group IV
7.3.5. Peer Group V
7.3.6. Peer Group VI
7.3.7. Peer Group VII
7.3.8. Peer Group VIII
7.4. Concluding Remarks
8. MERGERS AND ACQUISITIONS
8.1. Chapter Overview
8.2. In Vitro ADME Testing Services: Mergers
and Acquisitions
8.2.1. Cumulative Year-wise Trend
8.2.2. Geographical Activity
8.2.3. Ownership Change Matrix
8.2.4. Most Active Players: Analysis by Number of
Acquisitions
8.2.5. Key Value Drivers
8.2.6. Key Acquisitions: Deal Multiples
9. REGULATORY RECOMMENDATIONS AND
GUIDELINES
9.1. Chapter Overview
9.2. Regulatory Guidelines Issued by
International Regulatory Agencies
9.2.1. The
International Council for Harmonisation (ICH) of Technical Requirements for
Pharmaceuticals for Human Use
9.2.2. World Health Organization (WHO)
9.2.3. Organisation for Economic Co-operation and
Development (OECD)
9.3. Regulatory Guidelines Issued by Regional
Regulatory Agencies
9.3.1. United States Food and Drug Administration
(USFDA), US
9.3.2. European Medicine Agency (EMA), Europe
9.3.3. Ministry of Health, Labour and Welfare (MHLW),
Japan
9.4. In Vitro ADME Testing Service Providers:
Information on Regulatory Approval
10. MARKET FORECAST
10.1. Chapter Overview
10.2. Forecast Methodology and Key Assumptions
10.3. Overall In Vitro ADME Testing Services
Market, 2019-2030
10.4. In Vitro ADME Testing Services Market:
Distribution by Regions, 2019-2030
10.4.1. In Vitro ADME Testing Services Market in North
America, 2019-2030
10.4.1.1.
In Vitro ADME Testing Services Market in the US, 2019-2030
10.4.1.2.
In Vitro ADME Testing Services Market in Canada, 2019-2030
10.4.2. In Vitro ADME Testing Services Market in
Europe, 2019-2030
10.4.2.1.
In Vitro ADME Testing Services Market in Germany, 2019-2030
10.4.2.2.
In Vitro ADME Testing Services Market in France, 2019-2030
10.4.2.3.
In Vitro ADME Testing Services Market in the UK, 2019-2030
10.4.2.4.
In Vitro ADME Testing Services Market in Italy, 2019-2030
10.4.2.5.
In Vitro ADME Testing Services Market in Spain, 2019-2030
10.4.2.6.
In Vitro ADME Testing Services Market in Rest of Europe, 2019-2030
10.4.3. In Vitro ADME Testing Services Market in
Asia-Pacific and Rest of the World, 2019-2030
10.4.3.1.
In Vitro ADME Testing Services Market in Japan, 2019-2030
10.4.3.2.
In Vitro ADME Testing Services Market in China, 2018-2028
10.4.3.3.
In Vitro ADME Testing Services Market in India, 2019-2030
10.4.3.4.
In Vitro ADME Testing Services Market in Rest of the World, 2019-2030
10.5. In Vitro ADME Testing Services Market:
Distribution by Type of Services, 2019-2030
10.5.1. In Vitro ADME Testing Services Market for
Absorption Testing, 2019-2030
10.5.2. In Vitro ADME Testing Services Market for
Distribution Testing, 2019-2030
10.5.3. In Vitro ADME Testing Services Market for
Metabolism and Elimination Testing, 2019-2030
10.6. In Vitro ADME Testing Services Market:
Distribution by Type of Assays, 2019-2030
10.6.1. In Vitro ADME Testing Services Market for
Caco-2 Permeability Assay, 2019-2030
10.6.2. In Vitro ADME Testing Services Market for
PAMPA Permeability Assay, 2019-2030
10.6.3. In Vitro ADME Testing Services Market for MDCK
Permeability Assay, 2019-2030
10.6.4. In Vitro ADME Testing Services Market for
Protein Binding Assay, 2019-2030
10.6.5. In Vitro ADME Testing Services Market for
Blood Brain Barrier Assay, 2019-2030
10.6.6. In Vitro ADME
Testing Services Market for Assays for Studying Blood to Plasma Ratio,
2019-2030
10.6.7. In Vitro ADME Testing Services Market for
Metabolic Stability / Clearance Assay, 2019-2030
10.6.8. In Vitro ADME Testing Services Market for Enzyme
Induction Assay, 2019-2030
10.6.9. In Vitro ADME Testing Services Market for
Enzyme Inhibition Assay, 2019-2030
10.6.10. In Vitro ADME Testing Services Market for
Metabolite Profiling and Screening / Identification Assay, 2019-2030
10.6.11.
In Vitro ADME Testing Services Market for Metabolite Production Assay,
2019-2030
10.6.12.
In Vitro ADME Testing Services Market for Reaction Phenotyping Assay, 2019-2030
10.6.13.
In Vitro ADME Testing Services Market for Transporter Interactions Assay,
2019-2030
10.7. In Vitro ADME Testing Services Market:
Distribution by Type of Molecules, 2019-2030
10.7.1. In Vitro ADME Testing Services Market for
Small Molecules, 2019-2030
10.7.2. In Vitro ADME Testing Services Market for
Biologics, 2019-2030
10.8. In Vitro ADME Testing Services Market:
Distribution by Therapeutic Areas, 2019-2030
10.8.1. In Vitro ADME Testing Services Market for
Blood Disorders, 2019-2030
10.8.2. In Vitro ADME Testing Services Market for
Cardiovascular Disorders, 2019-2030
10.8.3. In Vitro ADME Testing Services Market for
Gastrointestinal and Digestive Disorders, 2019-2030
10.8.4. In Vitro ADME Testing Services Market for
Hormonal Disorders, 2019-2030
10.8.5. In Vitro ADME Testing Services Market for
Infectious Diseases, 2019-2030
10.8.6. In Vitro ADME Testing Services Market for
Immunological Disorders, 2019-2030
10.8.7. In Vitro ADME Testing Services Market for
Mental Disorders, 2019-2030
10.8.8. In Vitro ADME Testing Services Market for
Metabolic Disorders, 2019-2030
10.8.9. In Vitro ADME Testing Services Market for
Neurological Disorders, 2019-2030
10.8.10.
In Vitro ADME Testing Services Market for Cancers, 2019-2030
10.8.11.
In Vitro ADME Testing Services Market for Respiratory Disorders, 2019-2030
10.8.12.
In Vitro ADME Testing Services Market for Skin Disorders, 2019-2030
10.8.13.
In Vitro ADME Testing Services Market for Urogenital Disorders, 2019-2030
10.8.14.
In Vitro ADME Testing Services Market for Other Disorders, 2019-2030
10.8.15. In Vitro ADME Testing Services Market: Market Attractiveness
Analysis by Therapeutic Areas, 2019-2030
10.9. In Vitro ADME Testing Services Market:
Distribution by Type of Sponsors, 2019-2030
10.9.1. In Vitro ADME Testing Services Market for
Industry Players, 2019-2030
10.9.2. In Vitro ADME Testing Services Market for
Non-Industry Players, 2019-2030
11. CONCLUSION
11.1. Conducting
In Vitro ADME Studies During the Early Stages of Drug Development has
Demonstrated the Potential to Improve the Probability of Clinical Success
11.2. The Contract
Services Landscape Features Several Capable CROs Offering Services for In Vitro
ADME Testing; Most of these Companies are based in North America and Europe
11.3. Current
Market Leaders Have Vast In Vitro ADME Testing Service Portfolios, Drug Metabolism-related
Assays Represent the Major Fraction
11.4. Stakeholders
are Actively Expanding their Existing Capabilities to Cater to the Increasing
Demand; this is Evident in the Number of Acquisitions Reported over the Past
Decade
11.5. Driven by
the Need to Optimize the Drug Discovery and Development Process, the In Vitro
ADME Testing Services Market is Expected to Grow at a Healthy Pace in the
Foreseen Future
12. EXECUTIVE INSIGHTS
12.1. Chapter Overview
12.2. 490 BioTech
12.2.1. Company Snapshot
12.2.2. Interview Transcript: Dan Close, Chief
Scientific Officer
12.3. JRF Global
12.3.1. Company Snapshot
12.3.2. Interview
Transcript: Sridhar Iyer, Director and Global Head, Business Development and
Sarang Gorte, Assistant Manager, Business Development
13.
APPENDIX I: TABULATED DATA
14.
APPENDIX II: LIST OF COMPANIES AND
ORGANIZATIONS
Contact Details
Gaurav Chaudhary
+1 (415) 800 3415