Global
Hematopoietic Stem Cell Transplantation Market: Overview
Hematopoietic stem cells (HSCs) are present in the
bone marrow and blood. They are also known as hematopoietic progenitor cells
(HPCs). Hematopoietic stem cells are capable of producing mature blood cells,
such as platelets, white blood cells, and red blood cells. These cells are used
in the treatment of different types of malignant diseases (e.g. lymphoma,
leukemia) and non-malignant (e.g. hemoglobinopathies, bone marrow failure) to
rebuild or replace a patient's hematopoietic system. This type of treatment is
known as stem cell transplant or bone marrow transplant. Hematopoietic stem
cells have also been used in clinical trials with U.S. FDA oversight for the
treatment of genetic diseases, autoimmune diseases, and other indications. Over
the last 30 years, the hematopoietic stem cells transplantation market has seen
a rapid and constant expansion with advancements in lifesaving technologies.
Hematopoietic stem cell transplantation brings about restoration of the
patient’s medullary and immune function while treating a diverse range of about
70 non-hematological and hematological disorders. Overall, hematopoietic stem
cells transplantation is used in the treatment of immunological, oncological,
non-malignant, hematological, malignant, and hereditary diseases.
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There are two types of stem cell transplants:
allogeneic and autologous. Allogeneic HSCT involves the replacement of diseased
or damaged cells with cells from a healthy donor. The donor’s tissue type needs
to match the receiver’s tissue type as closely as possible to help prevent the
risk of problems with the transplant. Allogeneic transplantation is used for
therapeutic intervention of patients with hematological disorders (cancerous or
non-cancerous). Autologous HSCT replaces diseased or damaged cells with the
patient’s own stem cells. Harvesting of a patient’s stem cells is done before
chemotherapy, and harvested stem cells are then transplanted back into the
patient after treatment. Based on the source of hematopoietic stem cells, there
are three types of HSCTs: cord blood transplant, peripheral blood stem cell
transplant, and bone marrow transplant (BMT).
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Global
Hematopoietic Stem Cell Transplantation Market: Key Trends
The global hematopoietic stem cell transplantation
market is expected to expand at a rapid pace, due to a rise in the prevalence
of hematopoietic disorders, increase in success rates of transplantation, and
increase in the aging population across the world. According to a research
report by the Scientific America, transplantation rates over the globe have
increased from 50,000 HSC transplants per year in 2012 to 75,000 HSC
transplants per year in 2015. However, high cost of transplantation and lack of
funding for organizations such as the Worldwide Network for Blood & Marrow
Transplantation (WBMT) are expected to restrain the global hematopoietic stem cell
transplantation market during forecast period.
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Global
Hematopoietic Stem Cell Transplantation Market: Segmentation
The global hematopoietic stem cell transplantation
market can be segmented based on disease indication, transplant, application,
and region. In terms of disease indication, the market can be classified into
leukemia, lymphoproliferative disorders, and non-malignant disorders. Based on
transplant, the global hematopoietic stem cell transplantation market can be
categorized into autologous and allogeneic. Allogeneic transplant is projected
to continue to hold a dominant market share in terms of revenue during the
forecast period, due to the high average cost of allogeneic transplants as
compared to that of autologous transplants. In terms of application, the market
can be segmented into cord blood transplants, peripheral blood stem cells
transplants, and bone marrow transplants.
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Global
Hematopoietic Stem Cell Transplantation Market: Regional Analysis
Based on region, the global hematopoietic stem cell
transplantation market can be segmented into North America, Asia Pacific,
Europe, Latin America, and Middle East & Africa. Europe is projected to
lead the global market during the forecast period. The region’s dominance is
attributed to the overall increase in success rate of transplants, easy
technological applications, and high income of the population.
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Global
Hematopoietic Stem Cell Transplantation Market: Competitive Landscape
Key players operating in the global hematopoietic
stem cell transplantation market include Escape Therapeutics, Lonza Group,
Regen BioPharma Inc, Cesca Therapeutics Inc., Cryo-Save AG, CBR Systems,
Inc., Pluristem Therapeutics Inc., China Cord Blood Corporation, and ViaCord
Inc.
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