Genetic
Modification Therapies Market: Introduction
·
Genetic modification therapies enables the
transfer of genes for specific traits between species utilizing laboratory
techniques. Genetic modification therapy is a process of deletion, insertion, modification
or replacement of DNA bases in an organism. There are two different types of
gene therapies: Ex-Vivo Gene Therapy and In-Vivo Gene Therapy. Ex-vivo gene
therapy includes the transfer of genes in cultured cells and subsequent
reintroduction in a patient, while in In-vivo gene therapy, genes are directly
offered in cells of a particular tissue.
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·
Different techniques used in genetic
modification technologies are TALEN, CRISPR, ZFN, and CRISPR. These are
innovative genetic modification tools that enable researchers to modify the
parts of the genome by removing, adding, or altering sections of the DNA
sequence. CRISPR is a faster, accurate, and cheaper technique to modify DNA, as
compared to that of others methods including TALEN and ZFN. Transcription
activator-like effector nucleases (TALEN) is the technology generally used in
live cell gene modification. Zinc-finger nucleases (ZFNs) is an artificial
restriction enzyme that simplifies targeted modification of genome by creating
double-strand breaks in DNA at user-specified locations.
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Key
Drivers, Restraints, and Opportunities of Global Genetic Modification Therapies
Market
·
A genetic modification therapy was
considered unachievable at one of time; however, presently it has become widely
acceptable trend in various big and small companies. These trends have prompted
the establishment of various startups working on this therapy and are backed by
big companies. Additionally, new molecules to be used for gene therapy are
ready to reach the commercialization stage. All the factors mentioned here are
expected to drive the genetic modification therapies market.
·
Rising funding and investments for the
development and research of novel genetic modification technologies is also
anticipated to drive the market. For instance, in January 2018, the U.S.
National Institutes of Health (NIH) announced a grant US$ 190 million for
genome editing research. This novel program, Somatic Cell Genome Editing, is
expected to award funds to biomedical researchers over the next six years. The
support from major research organizations including NIH is likely to attract
more researchers in this field, which in turn may lead to advancements in
technology and subsequently, propel the market.
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·
High cost of genome modification
technologies is a major factor that is projected to restrain the genome
modification market during the forecast period. For instance, as per the fees
chart provided by Yale Genome Editing Center, in 2018, it charges between US$
8,000 and US$ 15,000 for gene editing facilities. The high cost associated with
genome modification facilities is estimated to hamper the market, especially in
emerging economies Including India, China, Brazil, and South Africa. Moreover,
genome modification is a highly complex technology and needs skilled
researchers, which further hinders its adoption.
·
On the other hand, unethical use of these
therapies and related concerns are likely to hamper the market. Limited
knowledge and lack of awareness about genetic modification therapies in
developing regions are also projected to restrain the genetic modification
therapies market.
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Europe
to Capture Major Share of Global Genetic Modification Therapies Market
In terms of
region, the global genetic modification therapies market can be segmented into
Europe, Latin America, North America, Asia Pacific, and Middle East &
Africa. Of these regions, Europe is expected to lead the global market during
the forecast period. Effective regulatory policies and efficient approval
process by the European regulatory body further boost the genetic modification
therapies market in the region.
The market
in North America is also anticipated to expand at a significant rate, as
several large and small companies are involved in overall clinical trials.
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Key
Players Operating in Global Genetic Modification Therapies Market
The global
genetic modification therapies market is highly fragmented, with the presence
of various key players. A large number of manufacturers hold a major
share in their respective regions.
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