Lentiviral Vectors:
Introduction
·
Lentiviral vectors are used as a medium to transfer foreign
genetic element into another cell. These vectors are produced from lentivirus,
which is defined by its long incubation period and can contaminate dividing and
non-dividing cells. Lentiviral are vectors that are descended from the virus,
known as human immunodeficiency virus, and used to transport genes in the
cells, such as mammalian cells. Such vectors are highly capable vehicles for
gene delivery for gene treatments.
·
Lentiviral vectors are utilized in the treatment of various type
diseases including HIV, Alzheimer’s disease and amyotrophic lateral sclerosis,
β-thalassemia, sickle cell disease, Metachromatic Leukodystrophy, X-linked
Adrenoleukodystrophy, and Wiskott-Aldrich Syndrome
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Key Drivers of Global
Lentiviral Vectors Market
·
Increase in research & development expenditure on lentiviral
vectors from key market players is a major factor driving the global lentiviral
vectors market. Increase in prevalence of diseases such as HIV, Alzheimer’s
disease, and amyotrophic lateral sclerosis, β-thalassemia, and sickle cell
disease is likely to drive the lentiviral vector market during the forecast
period. According to World Health Organization, around 38 million people are
living with HIV by globally.
·
Major market players are focused on inorganic growth strategies
such as collaborations and agreements for design and development of new
products. For instance, in October 2020, AVROBIO, Inc. signed a worldwide license
agreement and a collaborative research funding agreement with The University of
Manchester for an investigational lentiviral gene therapy for
mucopolysaccharidosis type II (MPS II), or Hunter syndrome. In June 2019,
Servier Laboratories signed a collaboration agreement with Yposkesi, Inc. for
the development of more novel and innovative vectors.
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First-generation
lentiviral vectors segment to be highly promising
·
Based on product type, the global lentiviral vectors market can
be segmented into first generation, second generation, and third generation
·
The first generation lentiviral vector segment accounted for a
prominent share of the global lentiviral vectors market in 2019. The segment is
expected to dominate the lentiviral vectors market, as it is used in the
treatment of various type of diseases. First-generation lentiviral vectors
contained a significant portion of the HIV genome, including the gag and pol
genes as well as several additional viral proteins.
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HIV segment to expand
significantly
·
In terms of disease indication, the global lentiviral vectors
market can be divided into HIV, β-thalassemia, X-linked Adrenoleukodystrophy,
Metachromatic Leukodystrophy, and Wiskott-Aldrich Syndrome. HIV was a prominent
segment, in terms of revenue, in 2019. It is anticipated to expand
significantly during the forecast period.
·
Increase in number of patients with HIV in developed as well as
developing region is likely to drive the segment. According to World Health
Organization, around 141,552 people were diagnosed with HIV in Europe in 2018.
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Hospitals segment to
expand considerably
·
In terms of end-user, the global lentiviral vectors market can
be divided into hospitals, clinics and research institute. The hospitals
segment accounted for a prominent share of the market, in terms of revenue, in
2019. It is anticipated to expand considerably during the forecast period.
Increase in number of patients with HIV, Alzheimer’s disease, amyotrophic
lateral sclerosis, β-thalassemia, and sickle cell disease that visit hospitals
is likely to boost the segment during the forecast period.
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North America to
dominate global lentiviral vectors market
·
In terms of region, the global lentiviral vectors market can be
categorized into North America, Europe, Asia Pacific, Latin America, and Middle
East & Africa
·
North America dominated the global lentiviral vectors market in
2019. It is expected to maintain its leading position during the forecast
period. Dominance of the region can be attributed to an increase in patients
with major chronic diseases such as HIV, cancer, neurological disorders,
hematological disorders, and rising number of research and development
programs.
·
The market in Asia Pacific is projected to expand at a
significantly high growth rate during the forecast period, owing to the launch
of new products and increase in demand for new treatment options for the
treatment of diseases such as HIV, cancer, and Alzheimer’s disease
Key Manufacturers
Operating in Global Market
The global lentiviral vectors
market was highly fragmented in 2019.
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