Small interfering RNA or siRNA
are a class of double-stranded RNA molecules, 20-25 base pairs in length.
Synthetic siRNA’s are producedansfected into the cell either by polymer based
transfection reagents, by cationic lipid or by electroporation i.e. physical
delivery of siRNA through plasma membrane holes made by chemical modification
or electrical field. siRNA are widely used to assess the individual
contributions of genes to an assortment of cellular phenotypes like cell
differentiation, insulin signaling, cytokinesis and apoptosis. Small
interfering RNA is a powerful tool for modulating gene expression by RNA
interference.
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Synthetic siRNA Market:
Dynamics
If compared to antibody-based
drugs and small molecule drugs, the chief advantages of siRNA are the
specificity determined by principles of complementary base pairing and ive due
to rapid developments happening in whole-genome sequencing and molecular
biology. Also, comprehensive nucleotide sequence databases have been
established, including cDNA databases, disease gene databases, and human
genomic databases laying a solid foundation for siRNA drug development. The
basic strategy of a siRNA drug is to treat the disease by silencing the
specific disease-promoting gene with wisely designed synthetic siRNA.path of
clinical use. siRNA are unstable under physiological conditions. When siRNA
traffics through the blood, it is easily digested by nucleases in the serum.
Selecting appropriate siRNA is more complicated than choosing a code
complementary to the sequence of the RNA to be silenced. This is because siRNA can
sometimes silence multiple genes and its effects can often be unpredictable. In
order to address this challenge, oinformatics tools to screen siRNA are
developed by reagent vendors.
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For synthetic siRNA experiments,
controls are an essential part. There are three types of controls used in siRNA
experiments, i.e. untreated control, negative control and positive control. The
untreated control creates a useful baseline reference for gene expression and
cell phenotypes levels. Negative controls help to separate sequence-specific
effects from experimental conditions of cellular responses. The positive
control ensures that the delivery method used is sufficient
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Synthetic siRNA Market:
Region-wise Outlook
Regionally, North America
represents the largest market for synthetic siRNA followed by Europe. Europe is
the second largest as well as the fastest growing market for synthetic siRNA.
siRNA reagents are expected to constitute the largest area of RNAi application
and synthesis of synthetic siRNA is anticipated to emerge as the fastest
growing application field. The discovery of siRNA's has opened new avenues for
therapeutic drug development. Many diseases caused by the inappropriate
activity of specific genes and the ability to silence such genes selectively
using synthetic siRNA’s
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Synthetic siRNA Market:
Key Players
The keyAmbion, B-Bridge,
Bioneer, Dharmacon (ThermoFisher), Invitrogen, Integrated DNA Technologies, MWG
Biotech, OligoEngine, Proligo (Sigma) and Qiagen.
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